Deutsch: N-Fluorbenzolsulfonimid / Español: N-Fluorobenzenosulfonimida / Português: N-Fluorobenzenossulfonimida / Français: N-Fluorobenzènesulfonimide / Italiano: N-Fluorobenzensulfonammide /

N-Fluorobenzenesulfonimide, often abbreviated as NFSI, is a chemical compound with significant applications in various industrial and chemical processes. This compound is known for its utility as a selective and powerful fluorination reagent. NFSI plays a crucial role in the introduction of fluorine atoms into organic molecules, making it valuable in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.

Application Areas of N-Fluorobenzenesulfonimide:

  • Chemical Synthesis: NFSI is widely used in chemical laboratories and industries for the introduction of fluorine atoms into organic molecules. It serves as a versatile reagent for the selective fluorination of aromatic compounds, alkenes, and other organic substrates.

  • Pharmaceuticals: The pharmaceutical industry relies on NFSI for the synthesis of fluorinated compounds used in drug discovery and development. Fluorinated drugs often exhibit improved pharmacokinetics and enhanced biological activity.

  • Agrochemicals: NFSI finds application in the agrochemical sector for the synthesis of fluorinated compounds used in pesticides and herbicides, which can enhance their effectiveness and stability.

Well-Known Examples of N-Fluorobenzenesulfonimide:

  • Fluorination Reagent: NFSI is a well-established fluorination reagent used in various chemical reactions for the introduction of fluorine atoms. It is often employed in research laboratories and industrial processes.

Risks Associated with N-Fluorobenzenesulfonimide:

  • Toxicity: N-Fluorobenzenesulfonimide is a potent fluorination reagent and should be handled with care. It can pose health risks, including skin and eye irritation, and should be used in a controlled environment with appropriate safety measures.

  • Chemical Reactivity: NFSI is a highly reactive compound that can react violently with incompatible substances. Proper storage and handling are essential to prevent accidents.


  • When working with NFSI, individuals should follow safety protocols, wear appropriate protective gear, and work in a well-ventilated area or under a fume hood.

  • Proper disposal methods should be employed for NFSI waste to ensure environmental safety.

History and Legal Basics:

N-Fluorobenzenesulfonimide has been utilized in chemical synthesis for several decades. Its handling and use are subject to various chemical safety regulations and guidelines enforced by national and international authorities.

Examples of Sentences:

  • The chemist used N-Fluorobenzenesulfonimide as a fluorination reagent to modify the chemical structure of the compound.
  • Researchers in the pharmaceutical industry rely on NFSI for the synthesis of fluorinated molecules with potential therapeutic applications.
  • The chemical plant follows strict safety procedures when handling N-Fluorobenzenesulfonimide to minimize risks to workers.
  • The use of NFSI in the agrochemical sector has led to the development of more effective and environmentally friendly pesticides.
  • The laboratory conducted experiments involving the fluorination of aromatic compounds using NFSI.

Similar Things or Synonyms:

  • Fluorination Reagents: Compounds and reagents used for introducing fluorine atoms into organic molecules, including various fluorinating agents.


N-Fluorobenzenesulfonimide (NFSI) is a chemical compound widely used in chemical synthesis, particularly for the selective fluorination of organic molecules. It finds application in various industries, including pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is essential for improving the properties of compounds. While NFSI is a valuable tool in chemical research and industrial processes, it should be handled with care due to its reactivity and potential health risks.


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