The acronym DME may refer to the following:
- Diastatic Malt Extract, a type of ingredient used in homebrewing (of beer)
- Dimethyl ether (or methoxymethane), a colorless, gaseous ether
- Dimethyoxethane (also glyme, monoglyme, dimethyl alcohol, ethylene glycol dimethyl ether, dimethyl cellosolve, DME), a type of clear, colorless, liquid ether that can be mixed with water, and is used as a solvent
- Diabetic Macular Edema, a type of ocular disease, specifically as a complication of diabetes
- Digital Multi Effects, a type of device used for video image manipulation, such as in live broadcasting and post-production
- Distance Measuring Equipment, a transponder-based radio navigation technology used by aircraft for determining distance